Maciej Migdał

scRNA-seq reveals the diversity of the developing cardiac cell lineage and molecular building blocks of the primary pacemaker

The paper uses scRNA-seq to analyze zebrafish heart development, identifying 18 cell populations and two genes critical for pacemaker function and heart rate regulation.

xcore: an R package for inference of gene expression regulators

xcore is an R package that models transcription factor activity using ChIP-seq signatures and gene expression data, demonstrating improved biological relevance in case studies.

Profiling subcellular localization of nuclear-encoded mitochondrial gene products in zebrafish

The paper profiles subcellular localization of nuclear-encoded mitochondrial gene products in zebrafish by analyzing RNA from different cellular fractions and quantifying transcriptomic changes in a chchd4a-/- mutation.

Transcriptome profile of the zebrafish atrioventricular canal reveals molecular signatures of pacemaker and valve mesenchyme

The paper profiles the transcriptome of the zebrafish atrioventricular canal to identify molecular signatures of pacemaker and valve mesenchyme, revealing conserved features with mammalian AV node and cardiac valves.

MiDAS - Meaningful Immunogenetic Data at Scale

MiDAS is an R package that enables statistical analysis of immunogenetic data, including HLA fine mapping, evolutionary divergence, and HLA-KIR interactions.

In silico tools for accurate HLA and KIR inference from clinical sequencing data empower immunogenetics on individual-patient and population scales

The paper evaluates computational tools for accurately inferring HLA alleles and KIR haplotypes from whole-genome or whole-exome sequencing data, showing high accuracy for both tasks.

Dynamics Of Cardiomyocyte Transcriptome And Chromatin Landscape Demarcates Key Events Of Heart Development

The paper analyzes transcriptomic and chromatin accessibility changes in zebrafish cardiomyocytes during heart development to identify key regulatory networks and their disruption in mutant lines.