Spatial control of mitochondrial retrograde signaling by nuclear pore-associated contact sites
Sahana Mitra, Giulia Burrone, Surya Rubarajan, Christophe Klein, Tyler Kwok, Suchit Gutta, Keyu Li, Elizaveta Berson, Joseph Orofino, Maria Dafne Cardamone, Michael D. Blower, Valentina Perissi
The paper shows that perinuclear clustering of mitochondria forms contact sites that facilitate GPS2 nuclear entry, essential for retrograde signaling, while TSPO-driven MNCS are not required.
bioRxiv · Jul 24, 2026 · PreprintCell Biology