Maria Dafne Cardamone

Spatial control of mitochondrial retrograde signaling by nuclear pore-associated contact sites

The paper shows that perinuclear clustering of mitochondria forms contact sites that facilitate GPS2 nuclear entry, essential for retrograde signaling, while TSPO-driven MNCS are not required.

DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin

This study shows that DOT1L promotes the degradation of c-MYC and MML-1 transcription factors on chromatin, regulating their target genes and potentially offering new cancer treatment strategies.

GPS2 regulates mitochondria biogenesis via mitochondrial retrograde signaling and chromatin remodeling of nuclear-encoded mitochondrial genes

This study identifies GPS2 as a mediator of mitochondrial retrograde signaling and a key activator of nuclear-encoded mitochondrial genes, revealing a novel mitochondria-nuclear communication pathway.