Michael D. Blower

This study shows that SAF-A/HNRNPU regulates euchromatin dynamics and is essential for maintaining nuclear envelope integrity through transcription-dependent mechanisms.

The paper shows that perinuclear clustering of mitochondria forms contact sites that facilitate GPS2 nuclear entry, essential for retrograde signaling, while TSPO-driven MNCS are not required.

The paper presents a method to assign SNPs to active or inactive X chromosomes using short read RNA and DNA sequencing, enabling allele-specific expression analysis in human cell lines without long read sequencing.

The paper shows that eIF4G cleavage products can either rescue or repress translation, revealing the closed-loop mRNP's role in translational silencing rather than initiation.

The paper shows that decreased tRNA abundance reduces translation elongation during mitosis, leading to reduced protein synthesis.

This study investigates the role of SAF-A's ATPase and RGG domains in nuclear processes, showing their involvement in XIST RNA maintenance, splicing, and cell proliferation.

The paper identifies reductive stress as a toxicity of biguanides like metformin, showing that fatty acid biosynthesis protects against this effect and could be targeted in cancer.

This study shows that CENP-A incorporation in human cells during G1 is independent of transcription and cohesin, contrasting findings in Drosophila.

This study identifies a minimal module for CPC midzone enrichment, showing KIF4A and KIF20A's roles in CPC localization during cytokinesis.

This study investigates the role of SAF-A's SAP domain and its serines S14 and S26 in X inactivation, gene expression, splicing, and cell proliferation, finding they are critical for XIST RNA localization and cell proliferation but not gene expression or splicing.