Pannexin 1 phosphorylation sites differentially modulate channel activity and physiological outcomes
Brooke L. O’Donnell, Luke S. Dunaway, Xuexin Zhang, Skylar A. Loeb, Zuzanna J. Juśkiewicz, Wyatt J. Schug, Susan A. Leonhardt, Abigail G. Wolpe, Melissa A. Luse, Samantha C. Bielefeld, Andrew K. J. Boyce, Madison D. Williams, Marie Billaud, Angela K. Best, Scott R. Johnstone, , Brant E. Isakson
This study identifies that PANX1 Y198 phosphorylation mediates ATP release, driving β-adrenergic vasoconstriction in vascular smooth muscle cells.
bioRxiv · Jul 17, 2026 · PreprintPhysiology