Brooke L. O’Donnell

This study shows that PANX1 ablation disrupts cell cycle progression and tumor structure in melanoma, suggesting it as a therapeutic target.

This study identifies that PANX1 Y198 phosphorylation mediates ATP release, driving β-adrenergic vasoconstriction in vascular smooth muscle cells.

This study shows arterial iron deficiency affects vasodilation by altering endothelial holo-alpha globin levels and NO signaling in female mice, but not in males.

This study investigates the interaction between PANX1 and the Hippo pathway in melanoma, showing PANX1 modulates YAP levels and identifies potential therapeutic targets.

This study investigates the differential roles of PANX1 and PANX3 in cutaneous squamous cell carcinoma, finding PANX1 promotes tumorigenesis while PANX3 suppresses it.