Author

Angela K. Best

University of Virginia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Brant E. IsaksoniD· 3 shared Scott R. JohnstoneiD· 3 shared Clare L. DennisoniD· 2 shared Kailynn RobertsiD· 2 shared Mark C. RentoniD· 2 shared Meghan W. SedovyiD· 2 shared Melissa R. LeafiD· 2 shared Paul D. LampeiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersPhysiology

Brant E. IsaksonORCID

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Author profile →

3 papers

Recent·Most cited

Pannexin 1 phosphorylation sites differentially modulate channel activity and physiological outcomes

Brooke L. O’Donnell, Luke S. Dunaway, Xuexin Zhang, Skylar A. Loeb, Zuzanna J. Juśkiewicz, Wyatt J. Schug, Susan A. Leonhardt, Abigail G. Wolpe, Melissa A. Luse, Samantha C. Bielefeld, Andrew K. J. Boyce, Madison D. Williams, Marie Billaud, Angela K. Best, Scott R. Johnstone, , Brant E. Isakson

This study identifies that PANX1 Y198 phosphorylation mediates ATP release, driving β-adrenergic vasoconstriction in vascular smooth muscle cells.

bioRxiv · Jul 17, 2026 · PreprintPhysiology

Injury Induced Connexin 43 Expression Regulates Endothelial Wound Healing

Meghan W. Sedovy, Mark C. Renton, Kailynn Roberts, Xinyan Leng, Clare L. Dennison, Caroline O Toler, Melissa R. Leaf, Paul D. Lampe, Angela K. Best, Brant E. Isakson, Scott R. Johnstone

This study shows that injury-induced Cx43 upregulation in endothelial cells promotes wound healing through gap junction-mediated communication, with phosphorylation playing a key role.

American Journal of Physiology-Heart and Circulatory Physiology · Oct 8, 2025Peer-reviewedPhysiology

A connexin 43 targeting peptide prevents blood vessel neointima formation

Mark C. Renton, Meghan W. Sedovy, Xinyan Leng, Farwah Iqbal, Melissa R. Leaf, Kailynn Roberts, Ramya C. Joshi, Arya Malek, Clare L. Dennison, Angela K. Best, Paul D. Lampe, Joseph W. Baker, Mark Joseph, George S. Baillie, Brant E. Isakson, Scott R. Johnstone

This study identifies a Cx43 targeting peptide that inhibits neointima formation in both human and mouse models by blocking cyclin E interactions and cell cycle progression.

bioRxiv · Sep 22, 2025 · PreprintPhysiology