Design and development of lysyl tRNA synthetase inhibitors, for the treatment of tuberculosis
Susan H. Davis, Michael Mathieson, Kirsteen I. Buchanan, Alice Dawson, Alasdair Smith, Mattia Cocco, Fábio K. Tamaki, John M. Post, Beatriz Baragaña, Chimed Jansen, Michael Kiczun, Fabio Zuccotto, Gavin Wood, Paul Scullion, Peter C. Ray, , Laura A. T. Cleghorn
The paper describes the development of lysyl tRNA synthetase inhibitors for tuberculosis treatment, optimizing compounds for preclinical and potential clinical use.
Journal of Medicinal Chemistry · Aug 1, 2025Peer-reviewedMicrobiology