Dirk Schnappinger

Identification and Evaluation of dibasic piperidines as novel cell wall inhibitors against Mycobacterium tuberculosis

The paper identifies and evaluates dibasic piperidines as novel cell wall inhibitors against Mycobacterium tuberculosis, showing activity across multiple media and differential sensitivity in resistant strains.

The Mycobacterium tuberculosis long-chain fatty acid resistome reveals the universal stress protein TB15.3 as essential for infection

This study identifies Mtb's LCFA resistome and shows TB15.3 as a critical metabolic regulator preventing LCFA toxicity during infection.

Mycobacterial EtfD contains an unusual linear cluster and enables β-oxidation to drive proton pumping by the electron transport chain

The paper identifies an unusual [3Fe-4S] cluster in EtfD from Mycobacterium smegmatis and shows its role in linking β-oxidation to proton pumping in the electron transport chain.

Metabolic control of drug resistance by a mycobacterial ion channel

The paper identifies Rv2571c as a mycobacterial ion channel that mediates pyrazinamide resistance by regulating cytoplasmic acidification.

Chlorotonils exhibit potent activity against Mycobacterium tuberculosis, while resistance is mediated by MmpR5-MmpL5

This study identifies chlorotonils as potent anti-Mtb agents and shows resistance is mediated by MmpR5-MmpL5.

Validating Conditionally Essential Targets: Discovery of the First Orally Effective Biotin Inhibitor against MycobacteriumTuberculosis

The paper develops an orally effective biotin inhibitor, C48, against Mycobacterium tuberculosis, demonstrating in vivo efficacy in a low-biotin mouse model.

Design and development of lysyl tRNA synthetase inhibitors, for the treatment of tuberculosis

The paper describes the development of lysyl tRNA synthetase inhibitors for tuberculosis treatment, optimizing compounds for preclinical and potential clinical use.

Integration of multi-modal measurements identifies critical mechanisms of tuberculosis drug action

This study introduces DECIPHAER, a tool that identifies critical mechanisms of tuberculosis drug action by integrating multi-modal data, revealing that respiration inhibition is more impactful than cell wall effects.

A periplasmic protein complex supports arabinofuranosyltransferase activity and mediates intrinsic drug resistance in Mycobacterium tuberculosis

This study identifies a periplasmic protein complex in Mtb that supports arabinofuranosyltransferase activity and contributes to intrinsic drug resistance.

Common biological features of Mycobacterium tuberculosis MmpL3 inhibitors

This study identifies common biological features of MmpL3 inhibitors, showing potent activity against M. tuberculosis and highlighting their potential as drug candidates.

Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis

This paper introduces PCL analysis to predict small molecule mechanisms of action in Mycobacterium tuberculosis using PROSPECT data, achieving high sensitivity and precision in MOA prediction.

A dose-response model for statistical analysis of chemical genetic interactions in CRISPRi screens

This paper introduces CRISPRi-DR, a dose-response model to analyze chemical-genetic interactions in CRISPRi screens, showing improved precision over existing methods.

Host-pathogen genetic interactions underlie tuberculosis susceptibility

This study identifies host-pathogen genetic interactions influencing tuberculosis susceptibility using a genetically diverse mouse panel and Mtb mutants.

Statistical Analysis of Variability in TnSeq Data Across Conditions Using Zero-Inflated Negative Binomial Regression

This paper introduces a statistical method using Zero-Inflated Negative Binomial regression to identify genes with significant variability in insertion counts across multiple conditions in TnSeq data.