Author
University of DundeeORCID 0000-0002-2881-5821Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Irene Georgiou, Colin Robinson, Sean N. O’Byrne…·Ian Hugh Gilbert
The paper develops bi-substrate inhibitors of SARS-CoV-2 nsp14 methyltransferase using structure-guided design, achieving nanomolar potency but limited cellular antiviral activity.
Mukul Rawat, Nonlawat Boonyalai, Cindy Smidt…·Lee M
This paper identifies targets of dual-active antimalarials by evolving resistance to nine compounds and validates them using CRISPR and molecular docking.
Susan H. Davis, Michael Mathieson, Kirsteen I. Buchanan…·Laura A. T. Cleghorn
The paper describes the development of lysyl tRNA synthetase inhibitors for tuberculosis treatment, optimizing compounds for preclinical and potential clinical use.
De Lin, Lesley-Anne Pearson, Shamshad Ahmad…·Ian Hugh Gilbert
The paper identifies a novel false-positive mechanism in RapidFire mass spectrometry and develops a pipeline to detect and mitigate these false positives in drug discovery.