BiophysicsNature CommunicationsPeer-reviewed
Remission spectroscopy resolves the mode of action of bedaquiline within living mycobacteria
Suzanna H. Harrison, Rowan C. Walters, Chen‐Yi Cheung…·James N. Blaza
This study uses remission spectroscopy to show bedaquiline inhibits ATP synthase in mycobacteria, redirecting electron flux through cytochrome bd oxidase and increasing O2 consumption, without uncoupling.