Gregory Murray Cook

This study investigates the roles of CydAB and Nox in E. faecalis metabolism under aerobic and hypoxic conditions, revealing Nox as the primary oxygen consumer and highlighting the complementary roles of respiratory and oxidative pathways.

This study uses remission spectroscopy to show bedaquiline inhibits ATP synthase in mycobacteria, redirecting electron flux through cytochrome bd oxidase and increasing O2 consumption, without uncoupling.

The paper determines the structure of mycobacterial NDH-2 bound to an inhibitor using cryo-EM, revealing structural features that could guide inhibitor design.

This paper demonstrates that the hydrogenase Huc from Mycobacterium smegmatis can drive ATP synthesis from air, providing a traceless energy source for bacterial survival during nutrient starvation.

The paper uses cryo-EM to show that malate-quinone oxidoreductase associates with the CIII2CIV2 supercomplex in mycobacteria, linking Krebs cycle and respiration.

This paper develops a non-invasive murine inhalation model using autoluminescent M. tuberculosis to rapidly assess drug efficacy against tuberculosis.

The paper identifies vulnerabilities in isoniazid-resistant Mycobacterium tuberculosis strains by analyzing metabolic and transcriptional changes in katG mutants.

This paper describes the discovery of a marine sponge-associated mycobacterium closely related to M. tuberculosis, which shares virulence factors but lacks virulence in mice.

This study identifies six new cytochrome bd inhibitor scaffolds through computational screening and validates their activity against Mycobacterium tuberculosis.

The paper uses Plasmodium cynomolgi to determine the delayed antimalarial effects of doxycycline and tafenoquine on P. vivax, finding IC50 values for doxycycline and tafenoquine.

This study uses CRISPR interference to assess the vulnerability and lethality of 96 target genes in Mycobacterium tuberculosis, identifying bactericidal and bacteriostatic effects across different cellular pathways.

This study identifies mutations in Mycobacterium tuberculosis that confer resistance to nitroimidazole antibiotics, highlighting the need for monitoring these mutations to manage antibiotic use.