Integrated single-cell analyses of affinity-tested B-cells enable the identification of a gene signature to predict antibody affinity.
Michele Chirichella, Matthew Ratcliff, Shuang Gu, Ricardo J. Miragaia, Massimo Domenico Sammito, Valentina Cutano, Suzanne E. Cohen, Davide Angeletti, Xavier Romero Ros, Darren J. Schofield
The paper identifies a transcriptomic signature, 'High Signature', that predicts high-affinity antibodies from B-cells without sequence analysis.
Cell Systems · Feb 1, 2026Peer-reviewedImmunology