Author

Matthew Ratcliff

AstraZeneca (United Kingdom)ORCID 0000-0003-4887-3786Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alexander MörseburgiD· 1 shared Anna BackmarkiD· 1 shared Audrey MelviniD· 1 shared Darren J. SchofieldiD· 1 shared Davide AngelettiiD· 1 shared Esther Guiu‐JuradoiD· 1 shared Keith BurlingiD· 1 shared Lutz JermutusiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Alexander MörseburgORCID

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2 papers

Recent·Most cited

ImmunologyCell SystemsPeer-reviewedFeb 1, 2026

Integrated single-cell analyses of affinity-tested B-cells enable the identification of a gene signature to predict antibody affinity.

Michele Chirichella, Matthew Ratcliff, Shuang Gu…·Darren J. Schofield

The paper identifies a transcriptomic signature, 'High Signature', that predicts high-affinity antibodies from B-cells without sequence analysis.

2 citationstop 4%

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Genetic & Genomic MedicineThe Journal of Applied Laboratory MedicinePeer-reviewedJul 7, 2022

The common H202D variant in GDF-15 does not affect its bioactivity but can significantly interfere with measurement of its circulating levels

Yanislava Karusheva, Matthew Ratcliff, Alexander Mörseburg…·Stephen O’Rahilly

The study shows that the H202D variant in GDF-15 does not affect its bioactivity but causes underreporting in R&D immunoassays, with correction equations provided.

36 citationstop 3%

humanproteomics

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