This paper presents a synthetic virology platform for rapidly prototyping influenza A virus mutants with altered antigenic sites using computational design and artificial synthesis.

bioRxiv · Oct 29, 2026 · PreprintSynthetic Biology

Aging promotes lung cancer metastasis through epigenetic ATF4 induction

Angana A. H. Patel, Jozefina J. Dzanan, Kevin X. Ali, Ella Äng Eklund, Samantha Alvarez, Dorota Raj, Martin Dankis, Ilayda Altinönder, Maria Schwarz, Kristell Le Gal, Emre Bedel, Ahmed Ezat El Zowalaty, Emma Jonasson, Heba Albatrok, Nadia Gul, , Volkan I. Sayin

This study shows aging promotes KRAS-driven lung cancer metastasis via ATF4 induction, which can be inhibited by glutaminase blockade.

Nature · Mar 11, 2026Peer-reviewedCancer Biology

Nasal tissue-resident memory CD4+ T cells persist after influenza A virus infection and provide heterosubtypic protection

Nimitha R. Mathew, Romain Gailleton, Lydia Scharf, Karin Schön, Josue Enriquez, Hannes Axelsson, Anneli Strömberg, Nils Yngve Lycke, Mats Bemark, Ka‐Wei Tang, Davide Angeletti

This study shows nasal tissue-resident memory CD4+ T cells persist after influenza infection and offer protection against different virus strains.

The Journal of Experimental Medicine · Mar 4, 2026Peer-reviewedImmunology

Integrated single-cell analyses of affinity-tested B-cells enable the identification of a gene signature to predict antibody affinity.

Michele Chirichella, Matthew Ratcliff, Shuang Gu, Ricardo J. Miragaia, Massimo Domenico Sammito, Valentina Cutano, Suzanne E. Cohen, Davide Angeletti, Xavier Romero Ros, Darren J. Schofield

The paper identifies a transcriptomic signature, 'High Signature', that predicts high-affinity antibodies from B-cells without sequence analysis.

Cell Systems · Feb 1, 2026Peer-reviewedImmunology

Antibodies, Memory B Cells, and Antigen Valency Reshape B Cell Responses to Drifted Influenza Virus Vaccination

Laura Reusch, Nimitha R. Mathew, Karin Schön, Ivan Košík, James S. Gibbs, Madeleine C. Mankowski, Danica F. Besavilla, Jonathan Wilson Yewdell, Mats Bemark, Davide Angeletti

This study investigates how vaccine antigen valency and pre-existing memory B cells influence B cell responses to drifted influenza virus, showing differential effects on germinal center dynamics and immunodominance.

bioRxiv · Nov 7, 2025 · PreprintImmunology

Computationally designed stem-epitope mimetics elicit broadly reactive antibodies

Sarah Wehrle, Andreas Scheck, Laura Reusch, Flavio Lemos Matassoli, Sandrine Georgeon, Karla M. Castro, Johannes Cramer, Wayne D. Harshbarger, Stéphane Rosset, Sarah F. Andrews, Karin Schön, Badiaa Bouzya, Ronan Nicolas Rouxel, Normand Blais, E. Malito, , Bruno E. Correia

This study designs stem-epitope mimetics using computational methods to elicit broadly reactive antibodies against influenza viruses.

bioRxiv · Jan 22, 2025 · PreprintBiochemistry

Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection

Zhao-Shan Chen, Hsiang‐Chi Huang, Xiangkun Wang, Karin Schön, Yane Jia, Michael Lebens, Danica F. Besavilla, Janarthan R. Murti, Yanhong Ji, Aishe A. Sarshad, Guohua Deng, Qiyun Zhu, Davide Angeletti

The paper identifies a nanobody that targets a conserved epitope on influenza A virus H7 hemagglutinin, providing cross-subtype neutralization and protection.

Nature Communications · Jan 9, 2025Peer-reviewedMicrobiology

Nuclear RNAi Modulates Influenza A Virus Infectivity By Downregulating Type-I Interferon Response

Hsiang-Chi Huang, Iwona Nowak, Vivian Lobo, Danica F. Besavilla, Karin Schön, Jakub O. Westholm, Carola Fernandez, Angana A.H. Patel, Clotilde Wiel, Volkan I. Sayin, Dimitrios G. Anastasakis, Davide Angeletti, Aishe A. Sarshad

This study shows that influenza A virus exploits nuclear RNAi by inducing AGO2 accumulation and silencing type-I interferon genes, and that arsenic trioxide can counteract this effect.

bioRxiv · Mar 7, 2024 · PreprintBiochemistry