cGAS-STING dependent type I IFN protects against Leptospira interrogans renal colonization in mice.
Suman Gupta, James Matsunaga, Bridget Ratitong, Sana Ismaeel, Diogo Garcia Valadares, Andrew Phillip West, Nagaraj Kerur, Christian Stehlik, Andrea Dorfleutner, Jargalsaikhan Dagvadorj, Jenifer Coburn, Andrea J. Wolf, Suzanne L. Cassel, David A. Haake, Fayyaz Shiraz Sutterwala
This study shows that cGAS-STING-dependent type I IFN signaling is required for host defense against Leptospira interrogans in mice by reducing renal colonization.
bioRxiv · Jun 2, 2025 · PreprintImmunology