Author

Jenifer Coburn

Medical College of WisconsinORCID 0000-0001-6460-2017Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Andrea DorfleutneriD· 1 shared Andrea J. WolfiD· 1 shared Andrew Phillip WestiD· 1 shared Anne L. SapiroiD· 1 shared Balyn W. ZaroiD· 1 shared Beth M. HayesiD· 1 shared Brandon Hochahn LeeiD· 1 shared Bridget RatitongiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Andrea DorfleutnerORCID

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2 papers

Recent·Most cited

cGAS-STING dependent type I IFN protects against Leptospira interrogans renal colonization in mice.

Suman Gupta, James Matsunaga, Bridget Ratitong, Sana Ismaeel, Diogo Garcia Valadares, Andrew Phillip West, Nagaraj Kerur, Christian Stehlik, Andrea Dorfleutner, Jargalsaikhan Dagvadorj, Jenifer Coburn, Andrea J. Wolf, Suzanne L. Cassel, David A. Haake, Fayyaz Shiraz Sutterwala

This study shows that cGAS-STING-dependent type I IFN signaling is required for host defense against Leptospira interrogans in mice by reducing renal colonization.

bioRxiv · Jun 2, 2025 · PreprintImmunology

P66 is a bacterial mimic of CD47 that binds the anti-phagocytic receptor SIRPα and facilitates macrophage evasion by Borrelia burgdorferi

Michal Caspi Tal, Paige S. Hansen, Haley A. Ogasawara, Qingying Feng, Regan F. Volk, Brandon Hochahn Lee, Sara E. Casebeer, Grace Blacker, Maia Shoham, Sarah Galloway, Anne L. Sapiro, Beth M. Hayes, Laughing Bear Torrez Dulgeroff, Tal Raveh, Venkata Raveendra Pothineni, , Balyn W. Zaro

This study identifies P66, a bacterial protein mimicking CD47, which binds SIRPα to evade macrophage phagocytosis, and shows its role in Lyme Disease pathogenesis.

bioRxiv · Apr 29, 2024 · PreprintImmunology