Author

Fayyaz Shiraz Sutterwala

Cedars-Sinai Medical CenterORCID 0000-0002-7338-3095Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Andrea DorfleutneriD· 1 shared Andrea J. WolfiD· 1 shared Andrew Phillip WestiD· 1 shared Blandine Victor· 1 shared Bridget RatitongiD· 1 shared Caroline Jefferies· 1 shared Catherine S. GrassoiD· 1 shared Christian StehlikiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Andrea DorfleutnerORCID

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2 papers

Recent·Most cited

Large oncosomes reprogram bone marrow mesenchymal stem cells to establish a pre-metastatic niche

Taylon Felipe Silva, Virgínia Márcia Concato, Fatima Bedier, Lauren Newman, Diána Kitka, Jamelle Brown, Blandine Victor, Minhyung Kim, Tatyana Vagner, Catherine S. Grasso, Dmitriy Sheyn, Sungyong You, Michael R. Freeman, Fayyaz Shiraz Sutterwala, Helen S. Goodridge, , Dolores Di Vizio

This study shows that large oncosomes reprogram bone marrow mesenchymal stem cells to create a pre-metastatic niche by inducing an interferon-driven inflammatory response.

Advanced Science · Oct 25, 2026Peer-reviewedCancer Biology

cGAS-STING dependent type I IFN protects against Leptospira interrogans renal colonization in mice.

Suman Gupta, James Matsunaga, Bridget Ratitong, Sana Ismaeel, Diogo Garcia Valadares, Andrew Phillip West, Nagaraj Kerur, Christian Stehlik, Andrea Dorfleutner, Jargalsaikhan Dagvadorj, Jenifer Coburn, Andrea J. Wolf, Suzanne L. Cassel, David A. Haake, Fayyaz Shiraz Sutterwala

This study shows that cGAS-STING-dependent type I IFN signaling is required for host defense against Leptospira interrogans in mice by reducing renal colonization.

bioRxiv · Jun 2, 2025 · PreprintImmunology