Selective covalent-allosteric tools to dissect Akt2
Lena Quambusch, Giovanni Danilo D’Angelo, Tonia Kirschner, Maria Beerbaum, Laura Depta, Fabian Schnecke, Janina Niggenaber, Sven Brandherm, Jörn Weisner, Matthias Philipp Müller, Leif Dehmelt, Daniel Rauh
This study develops Akt2-selective covalent-allosteric probes for functional studies and mechanistic insights into Akt2's role in health and disease.
bioRxiv · Jun 19, 2026 · PreprintCancer Biology