Author

Lena Quambusch

TU Dortmund UniversityORCID 0000-0002-1463-2450Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Andrian YangiD· 1 shared Chad A. Cowan· 1 shared Christine RowleyiD· 1 shared Daniel RauhiD· 1 shared Fabian Schnecke· 1 shared Florian T. MerkleiD· 1 shared Giovanni Danilo D’AngeloiD· 1 shared Hsiao‐Jou Cortina CheniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Andrian YangORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJun 19, 2026

Selective covalent-allosteric tools to dissect Akt2

Lena Quambusch, Giovanni Danilo D’Angelo, Tonia Kirschner…·Daniel Rauh

This study develops Akt2-selective covalent-allosteric probes for functional studies and mechanistic insights into Akt2's role in health and disease.

DOI 10.64898/2026.06.15.732341

experimental assaydrug response / drug discovery

𝕏 PostBluesky

NeurosciencebioRxivPreprintJul 18, 2023

Profiling human hypothalamic neurons reveals a candidate combination drug therapy for weight loss

Hsiao‐Jou Cortina Chen, Andrian Yang, Simone Mazzaferro…·Florian T. Merkle

The paper identifies a drug combination targeting human POMC neurons to reduce food intake and body weight using hPSC-derived neurons and mouse models.

3 citations

humanbulk RNA-seq

𝕏 PostBluesky