Loss of GdpP function in Staphylococcus aureus confers β-lactam-specific antibiotic tolerance and promotes invasive infection
Vedangi D. Hayatnagarkar, Stefano G. Giulieri, Raymond Poon, Swagata Bose, Joshua B. Parsons, Steven Y. C. Tong, Vance G. Fowler, Benjamin P. Howden, Som S. Chatterjee
This study shows that loss of GdpP function in Staphylococcus aureus leads to β-lactam antibiotic tolerance and increases mortality in infections, highlighting its clinical relevance in treatment failure.
bioRxiv · Aug 24, 2026 · PreprintMicrobiology