Joshua B. Parsons

Loss of GdpP function in Staphylococcus aureus confers β-lactam-specific antibiotic tolerance and promotes invasive infection

This study shows that loss of GdpP function in Staphylococcus aureus leads to β-lactam antibiotic tolerance and increases mortality in infections, highlighting its clinical relevance in treatment failure.

The innate immune protein calprotectin incapacitates the bactericidal activity of β-lactam antibiotics

This study shows that calprotectin reduces β-lactam antibiotic efficacy by inactivating bacterial autolysins through zinc sequestration, independent of bacterial growth.