Author

Sydni K. Holmes

The University of Texas Southwestern Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Organism:human· 1

Frequent Co-Authors

Rachel M. BaileyiD· 3 shared Irvin T. GarzaiD· 2 shared K. L. Knight· 2 shared Austin T. MarckxiD· 1 shared Bhavya ShahiD· 1 shared Brina SnyderiD· 1 shared Ibrahim YoussefiD· 1 shared Katherine M. Pearce· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersNeuroscience

Rachel M. BaileyORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Preclinical Development of a Vectorized Artificial miRNA Gene Therapy for Tauopathies

Irvin T. Garza, Brina Snyder, Sydni K. Holmes, Katherine M. Pearce, K. L. Knight, Rachel M. Bailey

This paper develops a gene therapy using artificial miRNA delivered via adeno-associated virus to reduce tau in a mouse model of tauopathy, showing efficacy even at late disease stages.

bioRxiv · Oct 12, 2025 · PreprintNeuroscience

AAV-mediated gene therapy for SLC13A5 citrate transporter disorder rescues epileptic and metabolic phenotypes

Lauren E. Bailey, Morgan K. Schackmuth, Raegan M. Adams, Irvin T. Garza, K. L. Knight, Sydni K. Holmes, Meghan M. Eller, MinJae Lee, Rachel M. Bailey

This study shows that AAV-mediated gene therapy in SLC13A5-deficient mice reduces extracellular citrate, normalizes electrophysiologic and sleep issues, and improves seizure resistance.

bioRxiv · Jul 3, 2025 · PreprintNeuroscience

Nitrous Oxide Enhances Focused Ultrasound Mediated Delivery of Viral Gene Therapy

Bhavya Shah, Rachel M. Bailey, Ibrahim Youssef, Sydni K. Holmes, Austin T. Marckx, Sandi Jo Estill-Terpac, Marc I. Diamond, Rajiv Chopra

Nitrous Oxide reduces microbubble and ultrasound pressure requirements for BBB opening and improves AAV9 vector delivery.

bioRxiv · Jul 11, 2021 · PreprintNeuroscience