Author

K. L. Knight

The University of Texas Southwestern Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Organism:human· 1

Frequent Co-Authors

Irvin T. GarzaiD· 2 shared Rachel M. BaileyiD· 2 shared Sydni K. Holmes· 2 shared A. J. Nelson· 1 shared A. Vuchkovska· 1 shared Brina SnyderiD· 1 shared J. G. Lee· 1 shared K. E. Jager· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersNeuroscience

Irvin T. GarzaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Preclinical Development of a Vectorized Artificial miRNA Gene Therapy for Tauopathies

Irvin T. Garza, Brina Snyder, Sydni K. Holmes, Katherine M. Pearce, K. L. Knight, Rachel M. Bailey

This paper develops a gene therapy using artificial miRNA delivered via adeno-associated virus to reduce tau in a mouse model of tauopathy, showing efficacy even at late disease stages.

bioRxiv · Oct 12, 2025 · PreprintNeuroscience

AAV-mediated gene therapy for SLC13A5 citrate transporter disorder rescues epileptic and metabolic phenotypes

Lauren E. Bailey, Morgan K. Schackmuth, Raegan M. Adams, Irvin T. Garza, K. L. Knight, Sydni K. Holmes, Meghan M. Eller, MinJae Lee, Rachel M. Bailey

This study shows that AAV-mediated gene therapy in SLC13A5-deficient mice reduces extracellular citrate, normalizes electrophysiologic and sleep issues, and improves seizure resistance.

bioRxiv · Jul 3, 2025 · PreprintNeuroscience

CD36hi monocytes play immunoregulatory roles in human umbilical cord blood

J. G. Lee, K. E. Jager, Y. Seki, A. J. Nelson, A. Vuchkovska, M. Nishimura, P. White, K. L. Knight, M. Iwashima

This study identifies CD36hi monocytes in umbilical cord blood that generate Foxp3+ T cells with suppressive functions, distinct from adult regulatory T cells.

bioRxiv · Nov 15, 2018 · PreprintImmunology