Marc I. Diamond

An N-terminal ATTR Fibril Segment Promotes Transthyretin Amyloid Nucleation and Polymorphism

This study identifies an N-terminal ATTR fibril segment that promotes TTR amyloid nucleation and polymorphism through structural compatibility and templating activity.

TAF15 amyloids propagate via defined motifs in a prion-like fashion

This study shows TAF15 forms amyloid fibrils and propagates prion-like between cells, identifying specific motifs that drive its aggregation in vitro and in cells.

Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) features CTE-like tau seeds in brain and spinal cord

This study identifies CTE-like tau seeds in ALS/PDC brain and spinal cord using alanine mutational scanning, suggesting ALS/PDC is a CTE-like tauopathy.

A functional amyloid scaffold shapes insect egg coats

The paper determines the atomic structure of insect chorion amyloid filaments and reveals their assembly principles, showing functional amyloids can operate in a regulated biological context.

Cysteines are critical determinants of spontaneous and seeded tau aggregation in cells

This study identifies cysteine residues as critical for tau aggregation and propagation in cells, both spontaneously and when seeded.

TDP-43 Aggregate Seeding Impairs Autoregulation and Causes TDP-43 Dysfunction

This study shows that TDP-43 aggregation through prion-like seeding impairs its autoregulation, leading to dysfunction and loss of function in cells.

Functional classification of tauopathy strains reveals the role of protofilament core residues.

The paper identifies amino acids critical for tau strain propagation by analyzing their role in amyloid templating across different tauopathies.

Selective Targeting of Pathogenic Tau Seeds via a Novel VHH

This paper identifies two VHH antibodies that selectively bind pathogenic tau seeds in AD and related tauopathies, showing potential for therapeutic and diagnostic applications.

Essential tremor with tau pathology features seeds indistinguishable in conformation from Alzheimer's disease and primary age-related tauopathy

This study identifies that tau assemblies in a subset of essential tremor cases with tau pathology are conformationally similar to Alzheimer's disease and primary age-related tauopathy.

Cryo-EM structure of Alzheimer disease tau filaments with PET ligand MK-6240

The paper determines the cryo-EM structure of Alzheimer's disease tau filaments bound by the PET ligand MK-6240, revealing key binding interactions that inform ligand design.

Endogenous recapitulation of Alzheimers disease neuropathology through human 3D direct neuronal reprogramming

This study uses 3D direct neuronal reprogramming of AD patient fibroblasts to recapitulate AD neuropathology, showing A{beta} deposition, tauopathy, and neuronal death, and identifies potential therapeutic targets.

Tau seeding without tauopathy

The paper detects seeding activity of tau assemblies in healthy human brains, suggesting normal physiological tau function that may contribute to disease when disrupted.

Anti-tau antibodies targeting a conformation-dependent epitope selectively bind seeds

The paper develops anti-tau antibodies that selectively bind pathological tau seeds in neurodegenerative diseases, supporting a model of conformational change at P301.

DnaJC7 specifically regulates tau seeding

This study identifies DnaJC7 as a specific regulator of tau seeding through its interaction with Hsp70, showing that its protective activity depends on the J domain and substrate binding site.

Endogenous pathology in tauopathy mice progresses via brain networks

The paper uses whole-brain imaging to show that tau pathology in mice propagates retrogradely through brain networks.

Network of hotspot interactions cluster tau amyloid folds

The paper uses an in silico alanine scan method to identify energetically important interactions in tau amyloid fibrils and classifies structures using machine learning.

Seed-competent tau monomer initiates pathology in PS19 tauopathy mice

The paper shows that seed-competent tau monomer (Ms) forms before insoluble fibrils in PS19 tauopathy mice, initiating pathology in a phosphorylation-independent manner.

Nitrous Oxide Enhances Focused Ultrasound Mediated Delivery of Viral Gene Therapy

Nitrous Oxide reduces microbubble and ultrasound pressure requirements for BBB opening and improves AAV9 vector delivery.

Alzheimers Disease risk modifier genes do not impact tau aggregate uptake, seeding or maintenance in cell models

This study tests whether AD risk modifier genes affect tau aggregate uptake, seeding, or maintenance in cell models and finds no effect.

Site-specific hyperphosphorylation of tau inhibits its fibrillization in vitro, blocks its seeding capacity in cells, and disrupts its microtubule binding; Implications for the native state stabilization of tau

This study shows that site-specific hyperphosphorylation of tau inhibits its aggregation and microtubule binding, challenging the hyperphosphorylation hypothesis of tau pathology.

Inert and seed-competent tau monomers suggest structural origins of aggregation

The paper identifies inert and seed-competent tau monomers, showing structural differences that influence aggregation potential.

Tau seeding activity anticipates phospho-tau pathology in Alzheimer’s disease

The paper quantifies tau seeding activity in Alzheimer’s disease tissue and finds it precedes phospho-tau pathology in specific brain regions.

Distinct glycosaminoglycan chain length and sulfation patterns required for cellular uptake of Tau, Aβ, and α-Synuclein

The paper identifies specific glycosaminoglycan (GAG) structural requirements for the uptake of Tau, Aβ, and α-synuclein aggregates by cells.