Targeting Cholesterol-Dependent Piezo1 Activation Impairs Amoeboid Migration in Melanoma Cells
Sylvia Kuang, Alleah G. Abrenica, Neelakshi Kar, Jeremy S. Logue
This paper identifies statins as inhibitors of bleb-based migration in melanoma cells by reducing cholesterol, which disrupts Piezo1 function and impairs migration in confined environments.
Proceedings of the National Academy of Sciences · Sep 9, 2026Peer-reviewedCancer Biology