Daniel A. Bose

DNA Damage Driven Viability Loss and Transcriptional Reprogramming in Chinese Hamster Ovary Cell Perfusion Culture

The paper identifies DNA damage accumulation as a key factor limiting viability in Chinese hamster ovary cells during perfusion culture, showing impaired DNA damage response and transcriptional dysfunction.

A universal protein ladder for standardisation of diverse FRET assays

The paper introduces a universal protein ladder to standardize FRET assays across different platforms and experimental conditions.

CBP-IDRs regulate acetylation and gene expression.

This study shows how different IDRs in CBP regulate its condensate properties, affecting gene expression and histone acetylation.

Mapping EGFR1 sorting domains in endosomes with a calibrated 3D expansion microscopy toolkit

This paper develops a 3D expansion microscopy toolkit to visualize and quantify nanoscale interactions in endosomes, revealing EGF and EGFR1 enrichment and Rab5a accumulation during endosomal maturation.

Amyotrophic Lateral Sclerosis-associated 3' UTR enhancer embedded within CAV1 risk gene

The paper identifies an ALS-associated enhancer within the CAV1 3' UTR, showing how non-coding variants disrupt enhancer function at multiple regulatory levels.

Notch signalling influences cell fate decisions and HOX gene induction in axial progenitors

This study shows Notch signalling promotes mesodermal fate and HOX gene activation in human NMPs while inhibiting neural fate through a feedback loop with FGF.

Locally acting transcription factors are required for p53-dependent cis-regulatory element activity

The paper investigates how local transcription factors influence p53-bound cis-regulatory elements, showing that co-regulatory factors and sequence context affect CRE activity and gene expression.