Activation of α7 Nicotinic Acetylcholine Receptor Inhibits Neutrophil ex vivo Swarming and Pulmonary Recruitment in Inflamed Mice through an Integrin αMβ2-dependent Mechanism
Jared L. Casteel, Tasha Phillips, Sanjay Singh, Téa Tsaava, Aisling Tynan, Valentin A. Pavlov, Alex R. Hopke, Valentin P. Yakubenko
This study shows that activating the α7 nicotinic acetylcholine receptor inhibits neutrophil migration and lung recruitment in inflamed mice by suppressing integrin αMβ2 activation.
bioRxiv · Oct 8, 2026 · PreprintImmunology