Cell BiologybioRxiv
Inhibition of the ubiquitin-proteasome system by a bioactivatable compound
T. A. Giovannucci, F. Salomons, M. Haraldsson…·N. Dantuma
The paper identifies CBK77, a bioactivatable compound that inhibits the ubiquitin-proteasome system by targeting NQO1, leading to cell death in cancer cells.
DOI 10.1038/s41419-021-04191-9