Author

T. A. Kohl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:whole-genome sequencing· 4 Organism:human· 3 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:variant calling· 1

Frequent Co-Authors

S. Niemann· 4 shared F. P. Maurer· 2 shared M. Merker· 2 shared R. Diel· 2 shared A. Indra· 1 shared A. Kupczok· 1 shared A. Sanchini· 1 shared B. Bunk· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersMicrobiology

S. Niemann

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Author profile →

4 papers

Recent·Most cited

Improving tuberculosis surveillance by detecting international transmission using publicly available whole-genome sequencing data

A. Sanchini, C. Jandrasits, J. Tembrockhaus, T. A. Kohl, C. Utpatel, F. P. Maurer, S. Niemann, W. Haas, B. Y. Renard, S. Kroeger

This study uses global whole-genome sequencing data to identify international tuberculosis transmission clusters, improving surveillance by connecting cases across countries.

Eurosurveillance · Jan 14, 2021Peer-reviewedMicrobiology

Global genomic population structure of Clostridioides difficile

M. Frentrup, Z. Zhou, M. Steglich, J. P. Meier-Kolthoff, M. Goker, T. Riedel, B. Bunk, C. Sproer, J. Overmann, M. Blaschitz, A. Indra, L. von Muller, T. A. Kohl, S. Niemann, C. Seyboldt, , U. Nubel

This study introduces EnteroBase, a database for C. difficile genomic data, showing it can identify related genomes with 89% consistency between cgMLST and SNPs.

Microbial Genomics · Aug 1, 2020Peer-reviewedMicrobiology

Insertion and deletion evolution reflects antibiotics selection pressure in a Mycobacterium tuberculosis outbreak.

M. Godfroid, T. Dagan, M. Merker, T. A. Kohl, R. Diel, F. P. Maurer, S. Niemann, A. Kupczok

This study identifies that insertions and deletions (indels) contribute to antibiotic resistance evolution in Mycobacterium tuberculosis during an outbreak, with indels showing a slower evolutionary rate than substitutions.

bioRxiv · Jan 28, 2020Microbiology

Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia

M. Merker, M. Barbier, H. Cox, J.-P. Rasigade, S. Feuerriegel, T. A. Kohl, R. Diel, S. Borrell, S. Gagneux, V. Nikolayevskyy, S. Andres, U. Nübel, P. Supply, T. Wirth, S. Niemann

The paper investigates the evolutionary mechanisms behind multidrug-resistant tuberculosis in Central Asia, finding that compensatory mutations enhance resistance and transmission success.

bioRxiv · May 31, 2018Evolutionary Biology