Author

M. Merker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Assay:whole-genome sequencing· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

S. Niemann· 3 shared R. Diel· 2 shared T. A. Kohl· 2 shared A. Kulik· 1 shared A. Kupczok· 1 shared A. Mitulski· 1 shared A. Spitaleri· 1 shared C. Meyners· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

S. Niemann

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

GlnA3Mt is able to glutamylate spermine but it is not essential for the detoxification of spermine in Mycobacterium tuberculosis

S. Krysenko, C. S. Emani, M. Bäuerle, M. Oswald, A. Kulik, C. Meyners, D. Hillemann, M. Merker, I. Wohlers, F. Hausch, H. Brötz-Oesterhelt, A. Mitulski, N. Reiling, W. Wohlleben

The paper shows that GlnA3Mt in M. tuberculosis can glutamylate spermine but is not essential for spermine detoxification, with efflux pumps playing a compensatory role.

bioRxiv · Dec 14, 2023 · PreprintMicrobiology

Deciphering Bedaquiline and Clofazimine Resistance in Tuberculosis: An Evolutionary Medicine Approach

L. Sonnenkalb, J. Carter, A. Spitaleri, Z. Iqbal, M. Hunt, K. Malone, C. Utpatel, D. M. Cirillo, C. Rodrigues, K. S. Nilgiriwala, the CRyPTIC Consortium, P. W. Fowler, M. Merker, S. Niemann

This study identifies 230 genomic variants associated with resistance to bedaquiline and clofazimine in tuberculosis using experimental evolution, genome sequencing, and structural modeling.

bioRxiv · Mar 19, 2021Microbiology

Insertion and deletion evolution reflects antibiotics selection pressure in a Mycobacterium tuberculosis outbreak.

M. Godfroid, T. Dagan, M. Merker, T. A. Kohl, R. Diel, F. P. Maurer, S. Niemann, A. Kupczok

This study identifies that insertions and deletions (indels) contribute to antibiotic resistance evolution in Mycobacterium tuberculosis during an outbreak, with indels showing a slower evolutionary rate than substitutions.

bioRxiv · Jan 28, 2020Microbiology

Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia

M. Merker, M. Barbier, H. Cox, J.-P. Rasigade, S. Feuerriegel, T. A. Kohl, R. Diel, S. Borrell, S. Gagneux, V. Nikolayevskyy, S. Andres, U. Nübel, P. Supply, T. Wirth, S. Niemann

The paper investigates the evolutionary mechanisms behind multidrug-resistant tuberculosis in Central Asia, finding that compensatory mutations enhance resistance and transmission success.

bioRxiv · May 31, 2018Evolutionary Biology