Vascular injury associated with ethanol intake is driven by AT1 receptor and mitochondrial dysfunction.
W. M. C. Awata, J. V. Alves, R. M. Costa, A. Bruder-Nascimento, S. Singh, G. S. Barbosa, C. R. Tirapelli, T. B. Nascimento
This study shows ethanol-induced vascular dysfunction is mediated by AT1 receptor activation and mitochondrial dysfunction, which can be mitigated by losartan.
bioRxiv · Sep 5, 2023Pharmacology & Toxicology