Loss of RNase J leads to multi-drug tolerance and accumulation of highly structured mRNA fragments in Mycobacterium tuberculosis
M. C. Martini, N. D. Hicks, J. Xiao, T. Barbier, J. Sixsmith, S. M. Fortune, S. S. Shell
This study shows that loss of RNase J in Mtb leads to drug tolerance and accumulation of structured mRNA fragments, highlighting its role in RNA metabolism and drug resistance.
bioRxiv · Feb 13, 2022Microbiology