Author

N. D. Hicks

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:whole-genome sequencing· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

S. M. Fortune· 4 shared Q. Liu· 3 shared S. Stanley· 3 shared X. Wang· 3 shared A. J. Vickers· 2 shared M. C. Chao· 2 shared A. M. Frey· 1 shared B. B. Aldridge· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersMicrobiology

S. M. Fortune

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Author profile →

4 papers

Recent·Most cited

Ongoing evolution of the Mycobacterium tuberculosis lactate dehydrogenase reveals the pleiotropic effects of bacterial adaption to host pressure

S. Stanley, X. Wang, Q. Liu, Y. Y. Kwon, A. M. Frey, N. D. Hicks, A. J. Vickers, S. Hui, S. M. Fortune

This study investigates the evolutionary adaptation of Mycobacterium tuberculosis lactate dehydrogenase (LldD2) under host pressure, showing its role in metabolic flexibility and virulence.

bioRxiv · Oct 9, 2023 · PreprintMicrobiology

High-throughput phenogenotyping of Mycobacteria tuberculosis clinical strains reveals bacterial determinants of treatment outcomes

S. Stanley, C. N. Spaulding, Q. Liu, M. R. Chase, D. T. M. Ha, P. V. K. Thai, N. H. Lan, D. D. A. Thu, N. L. Quang, J. Brown, N. D. Hicks, X. Wang, M. Marin, N. C. Howard, A. J. Vickers, , S. M. Fortune

This study uses high-throughput phenogenotyping to link Mtb genetic variants to clinical outcomes, identifying bacterial traits associated with treatment failure and transmission.

bioRxiv · Apr 9, 2023 · PreprintMicrobiology

Tuberculosis treatment failure associated with evolution of antibiotic resilience

Q. Liu, J. Zhu, C. L. Dulberger, S. Stanley, S. Wilson, E. S. Chung, X. Wang, P. Culviner, Y. J. Liu, N. D. Hicks, G. H. Babunovic, S. R. Giffen, B. B. Aldridge, E. C. Garner, E. J. Rubin, , S. M. Fortune

The paper identifies resR as a target of positive selection in Mtb clinical isolates, linking its mutations to antibiotic resilience and treatment failure.

bioRxiv · Mar 29, 2022Microbiology

Loss of RNase J leads to multi-drug tolerance and accumulation of highly structured mRNA fragments in Mycobacterium tuberculosis

M. C. Martini, N. D. Hicks, J. Xiao, T. Barbier, J. Sixsmith, S. M. Fortune, S. S. Shell

This study shows that loss of RNase J in Mtb leads to drug tolerance and accumulation of structured mRNA fragments, highlighting its role in RNA metabolism and drug resistance.

bioRxiv · Feb 13, 2022Microbiology