A Proteomic Platform to Identify Off-Target Proteins Associated with Therapeutic Modalities that Induce Protein Degradation or Gene Silencing
X. Liu, Y. Zhang, L. D. Ward, Q. Yan, T. Bohnuud, R. Hernandez, S. Lao, J. Yuan, F. Fan
The paper develops a proteomics platform to identify off-target proteins affected by PROTAC and RNAi therapies, using a selected off-target proteome and LC-MS/MS quantification.
bioRxiv · Nov 18, 2020Pharmacology & Toxicology