Analysis of Skin Cancers from Xeroderma Pigmentosum Patients Reveals Heterogeneous UV-Induced Mutational Profiles Shaped by DNA Repair
A. A. Yurchenko, F. Rajabi, T. Braz-Petta, H. Fassihi, A. Lehmann, C. Nishigori, I. Padioleau, K. Gunbin, L. Panunzi, F. Morice-Picard, P. Laplante, C. Robert, P. Kannouche, C. F. M. Menck, A. Sarasin, S. I. Nikolaev
The paper analyzes skin cancer genomes from Xeroderma Pigmentosum patients to show how NER activity shapes mutation rates and reveals POLH's role in bypassing UV-induced DNA lesions.
bioRxiv · Oct 14, 2022 · PreprintCancer Biology