Author

A. Sarasin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Assay:whole-genome sequencing· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. A. Yurchenko· 2 shared I. Padioleau· 2 shared A. Bellacosa· 1 shared A. Lehmann· 1 shared B. T. Matkarimov· 1 shared C. F. M. Menck· 1 shared C. Goding· 1 shared C. Kenny· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

A. A. Yurchenko

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Author profile →

3 papers

Recent·Most cited

Analysis of Skin Cancers from Xeroderma Pigmentosum Patients Reveals Heterogeneous UV-Induced Mutational Profiles Shaped by DNA Repair

A. A. Yurchenko, F. Rajabi, T. Braz-Petta, H. Fassihi, A. Lehmann, C. Nishigori, I. Padioleau, K. Gunbin, L. Panunzi, F. Morice-Picard, P. Laplante, C. Robert, P. Kannouche, C. F. M. Menck, A. Sarasin, S. I. Nikolaev

The paper analyzes skin cancer genomes from Xeroderma Pigmentosum patients to show how NER activity shapes mutation rates and reveals POLH's role in bypassing UV-induced DNA lesions.

bioRxiv · Oct 14, 2022 · PreprintCancer Biology

BRN2 is a non-canonical melanoma tumor-suppressor

M. Hamm, P. Sohier, V. Petit, J. Raymond, V. Delmas, M. Le Coz, F. Gesbert, C. Kenny, Z. Aktary, M. Pouteaux, F. Rambow, A. Sarasin, A. Bellacosa, L. Sanchez-del-Campo, L. Mosteo, , L. Larue

This study identifies BRN2 as a non-canonical tumor suppressor in melanoma, showing its role in initiation and progression through PTEN regulation and PI3K signaling.

bioRxiv · Jan 13, 2021Cancer Biology

XPC deficiency increases risk of hematologic malignancies through mutator phenotype and characteristic mutational signature

A. A. Yurchenko, I. Padioleau, B. T. Matkarimov, J. Soulier, A. Sarasin, S. Nikolaev

This study shows XPC deficiency leads to higher mutation rates and specific mutational signatures in hematologic malignancies, increasing cancer risk through a mutator phenotype.

bioRxiv · Jul 13, 2020Cancer Biology