A TIR-1/SARM1 phase transition underlies p38 immune pathway activation in the C. elegans intestine
N. D. Peterson, J. D. Icso, J. E. Salisbury, T. C. Rodriguez, P. Thompson, R. Pukkila-Worley
This paper shows that a phase transition of TIR-1/SARM1 in C. elegans activates the p38 immune pathway, linking protein oligomerization to immune response and pathogen defense.
bioRxiv · Aug 5, 2021Immunology