Transitional alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung models
T. Caracena, R. Blomberg, R. S. Hewawasam, D. W. H. Riches, C. M. Magin
This paper develops a 3D hydrogel model of lung tissue to study fibroblast activation in IPF, showing that transitional epithelial cells and microenvironmental stiffness synergistically drive myofibroblast activation.
bioRxiv · May 24, 2022Bioengineering