R. Blomberg

Hydrogel-embedded precision-cut lung slices support ex vivo culture of in vivo-induced premalignant lung lesions

This study shows that hydrogel-embedded precision-cut lung slices can maintain premalignant lung lesions for six weeks and respond to a cancer prevention agent.

Tissue-engineered models of lung cancer premalignancy

This paper develops a tissue-engineered model of human lung cancer premalignancy using hydrogel-embedded lung slices exposed to cigarette smoke carcinogens, showing the formation of premalignant lesions and testing chemoprevention agents.

Chemical modification of human decellularized extracellular matrix for incorporation into phototunable hybrid-hydrogel models of tissue fibrosis

This paper develops a phototunable hybrid-hydrogel system using chemically modified human decellularized extracellular matrix to study fibrosis-related mechanosensing and cell-matrix interactions.

Transitional alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung models

This paper develops a 3D hydrogel model of lung tissue to study fibroblast activation in IPF, showing that transitional epithelial cells and microenvironmental stiffness synergistically drive myofibroblast activation.