Microtubule Nucleation by Single Human γTuRC in a Partly Open Asymmetric Conformation
T. Consolati, J. Locke, J. Roostalu, J. Asthana, W. M. Lim, J. Gannon, F. Martino, A. Costa, T. Surrey
This study characterizes the nucleation properties of human γTuRC using TIRF microscopy and cryo-EM, revealing an asymmetric conformation that explains its kinetic inhibition of microtubule nucleation.
bioRxiv · Nov 23, 2019 · PreprintBiochemistry