Author

J. Roostalu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:cryo-EM· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

T. Surrey· 4 shared A. Costa· 1 shared B. J. Greber· 1 shared B. J. LaFrance· 1 shared C. McCollum· 1 shared C. Thomas· 1 shared D. Normanno· 1 shared E. Nogales· 1 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersBiochemistry

T. Surrey

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural transitions in the GTP cap visualized by cryo-EM of catalytically inactive microtubules

B. J. LaFrance, J. Roostalu, G. Henkin, B. J. Greber, R. Zhang, D. Normanno, C. McCollum, T. Surrey, E. Nogales

The paper uses cryo-EM to visualize the structure of GTP-bound microtubules, revealing an expanded lattice and closed seam that stabilize the GTP cap.

bioRxiv · Aug 13, 2021Biophysics

Microtubule Nucleation by Single Human γTuRC in a Partly Open Asymmetric Conformation

T. Consolati, J. Locke, J. Roostalu, J. Asthana, W. M. Lim, J. Gannon, F. Martino, A. Costa, T. Surrey

This study characterizes the nucleation properties of human γTuRC using TIRF microscopy and cryo-EM, revealing an asymmetric conformation that explains its kinetic inhibition of microtubule nucleation.

bioRxiv · Nov 23, 2019 · PreprintBiochemistry

The speed of GTP hydrolysis determines GTP cap size and controls microtubule stability

J. Roostalu, C. Thomas, N. I. Cade, S. Kunzelmann, I. A. Taylor, T. Surrey

This study shows that GTP hydrolysis speed affects GTP cap size and microtubule stability by influencing EB protein binding and regulatory hub formation.

bioRxiv · Sep 23, 2019Biochemistry

Combinatorial Regulation Of The Balance Between Dynein Microtubule End Accumulation And Initiation Of Directed Motility

R. Jha, J. Roostalu, M. Trokter, T. Surrey

The paper investigates how dynein activity is regulated by different regulators, revealing distinct pools of dynein with opposing preferences for binding regulators and different motility behaviors.

bioRxiv · Apr 11, 2017Cell Biology