Platinum-Induced Ubiquitination of Phosphorylated H2AX by RING1A is Mediated by Replication Protein A in Ovarian Cancer
S. Sriramkumar, T. D. Matthews, A. H. Ghobashi, S. A. Miller, P. S. VanderVere-Carozza, K. S. Pawelczak, K. P. Nephew, J. J. Turchi, H. M. O'Hagan
This study identifies RING1A-mediated ubiquitination of phosphorylated H2AX at platinum DNA damage sites in ovarian cancer, revealing its role in DNA repair and platinum resistance.
Molecular Cancer Research · Nov 1, 2020Peer-reviewedCancer Biology