P. S. VanderVere-Carozza

This paper develops RPA inhibitors that induce RPA exhaustion, showing anticancer activity in vitro and in vivo, and identifies RPA expression as a prognostic and predictive biomarker.

This study identifies RING1A-mediated ubiquitination of phosphorylated H2AX at platinum DNA damage sites in ovarian cancer, revealing its role in DNA repair and platinum resistance.

This study discovers and develops a new class of DNA-PK inhibitors that target the Ku-DNA interaction, enhancing the efficacy of ionizing radiation and gene editing.