Author

A. H. Ghobashi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

H. M. O'Hagan· 4 shared C. A. Ladaika· 2 shared K. P. Nephew· 2 shared S. A. Miller· 2 shared S. Sriramkumar· 2 shared H. M. OHagan· 1 shared J. J. Turchi· 1 shared J. W. Kimani· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersCancer Biology

H. M. O'Hagan

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5 papers

Recent·Most cited

Single-cell multi-omics reveals insights into differentiation of rare cell types in mucinous colorectal cancer

C. A. Ladaika, A. H. Ghobashi, W. C. Boulton, S. A. Miller, H. M. O'Hagan

The paper uses single-cell multi-omics to study EEC differentiation in mucinous colorectal cancer, identifies STAT3 as a regulator, and discovers a rare cancer cell type with neuron-like features.

bioRxiv · Feb 1, 2024 · PreprintCancer Biology

Single-cell profiling reveals the impact of genetic alterations on the differentiation of inflammation-induced colon tumors

A. H. Ghobashi, R. Lanzloth, C. A. Ladaika, H. M. O'Hagan

This study uses single-cell RNA-sequencing to show how genetic mutations in a mouse model alter colon tumor differentiation in inflammation-induced colorectal cancer.

bioRxiv · Nov 30, 2023Cancer Biology

Activation of AKT induces EZH2-mediated beta-catenin trimethylation in colorectal cancer

A. H. Ghobashi, T. T. Vuong, J. W. Kimani, H. M. O'Hagan

This study shows that AKT activation in colorectal cancer leads to EZH2-mediated beta-catenin methylation, enhancing gene expression and promoting tumor progression.

bioRxiv · Jan 31, 2023Cancer Biology

Platinum-Induced Mitochondrial OXPHOS Contributes to Cancer Stem Cell Enrichment in Ovarian Cancer

S. Sriramkumar, R. Sood, T. D. Huntington, A. H. Ghobashi, W. Wang, K. P. Nephew, H. M. OHagan

This study shows platinum treatment increases mitochondrial activity and OXPHOS in ovarian cancer cells, leading to enrichment of cancer stem cells, which can be blocked by OXPHOS inhibitors.

bioRxiv · Feb 1, 2022Cancer Biology

Platinum-Induced Ubiquitination of Phosphorylated H2AX by RING1A is Mediated by Replication Protein A in Ovarian Cancer

S. Sriramkumar, T. D. Matthews, A. H. Ghobashi, S. A. Miller, P. S. VanderVere-Carozza, K. S. Pawelczak, K. P. Nephew, J. J. Turchi, H. M. O'Hagan

This study identifies RING1A-mediated ubiquitination of phosphorylated H2AX at platinum DNA damage sites in ovarian cancer, revealing its role in DNA repair and platinum resistance.

Molecular Cancer Research · Nov 1, 2020Peer-reviewedCancer Biology