Author

T. D. O'Brien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. F. Modiano· 2 shared A. J. Donnelly· 1 shared A. J. Schulte· 1 shared A. Khammanivong· 1 shared A. L. Sarver· 1 shared A. M. Frantz· 1 shared A. Montoya· 1 shared A. R. Ortiz· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

J. F. Modiano

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Author profile →

4 papers

Recent·Most cited

Global ecological and biogeochemical impacts of pelagic tunicates

J. Y. Luo, C. A. Stock, N. Henschke, J. P. Dunne, T. D. O'Brien

This study assesses the ecological and biogeochemical impact of pelagic tunicates by integrating them into a global ocean model, showing their significant contribution to carbon export and detritus production.

Progress in Oceanography · Jul 1, 2022Peer-reviewedEcology

Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning

K. Makielski, A. J. Donnelly, A. Khammanivong, M. C. Scott, A. R. Ortiz, D. C. Galvan, H. Tomiyasu, C. Amaya, K. Ward, A. Montoya, J. R. Garbe, L. J. Mills, G. R. Cutter, J. M. Fenger, W. C. Kisseberth, , J. F. Modiano

The paper develops a gene signature using exosomal RNA from canine osteosarcoma xenografts and machine learning to detect residual disease in dogs, showing improved remission outcomes in validation samples.

Laboratory Investigation · Dec 1, 2021Peer-reviewedCancer Biology

Self-organized emergence of hyaline cartilage in hiPSC-derived multi-tissue organoids

M. Li, J. E. Abrahante, A. Vegoe, Y. W. Chai, B. Lindborg, F. Toth, P. A. Larsen, T. D. O'Brien

This study develops a protocol for generating hyaline cartilage from hiPSC-derived multi-tissue organoids and identifies molecular pathways involved in its self-organized emergence and articular cartilage development.

bioRxiv · Sep 21, 2021 · PreprintCell Biology

Hemangiosarcoma Cells Promote Conserved Host-Derived Hematopoietic Expansion

J. H. Kim, A. J. Schulte, A. L. Sarver, M. G. Angelos, A. M. Frantz, C. L. Foster, T. D. O'Brien, I. Cornax, M. G. O'Sullivan, N. Cheng, M. Lewellen, L. Oseth, S. Kumar, S. Bullman, C. S. Pedamallu, , J. F. Modiano

This study shows that hemangiosarcoma cells create a microenvironment that supports hematopoietic expansion, resembling bone marrow niche cells.

bioRxiv · May 21, 2021Cancer Biology