Cancer BiologybioRxiv
The developmental stage of the medulloblastoma cell-of-origin restricts Hedgehog pathway usage and drug sensitivity
M. J. Smit, I. Armandari, I. Bockaj…·S. Bruggeman
The paper shows that the developmental stage of medulloblastoma cell-of-origin affects Hedgehog pathway usage and drug sensitivity, with downstream pathway targets being more effective in infant patients.