M. J. Smit

Pharmacological characterization and radiolabeling ofVUF15485, a high-affinity small-molecule agonist for theatypical chemokine receptor ACKR3

This paper characterizes VUF15485, a high-affinity ACKR3 agonist, and reports its radiolabeling and binding properties.

Luminescence-based screening for extracellular vesicle release modulators reveals a role for PI4KIIIβ in exosome biogenesis upon lysosome inhibition

This study identifies PI4KIIIβ as a key mediator of exosome secretion upon lysosome inhibition using a luminescence-based screening approach.

Computationally designed GPCR quaternary structures bias signaling pathway activation

The paper designs GPCR quaternary structures to bias signaling pathway activation and identifies a conformational switch controlling G protein vs β-arrestin recruitment.

Targeting the latent human cytomegalovirus reservoir with virus specific nanobodies

This study develops a nanobody that partially inhibits HCMV receptor signaling and enhances T-cell killing of latently infected monocytes, offering a potential therapy for clearing HCMV reservoirs in transplant patients.

The developmental stage of the medulloblastoma cell-of-origin restricts Hedgehog pathway usage and drug sensitivity

The paper shows that the developmental stage of medulloblastoma cell-of-origin affects Hedgehog pathway usage and drug sensitivity, with downstream pathway targets being more effective in infant patients.

Monitoring ligand-induced changes in receptor conformation with NanoBiT conjugated nanobodies

The paper uses nanobodies conjugated with NanoBiT to monitor ligand-induced conformational changes in the CXCR4 receptor.