KRASG12D mutant cells are outcompeted by wild type neighbours in adult pancreas in an EPHA2-dependent manner.
W. Hill, A. Zaragkoulias, B. Salvador, G. Parfitt, M. Alatsatianos, A. Padilha, S. Porazinski, T. E. Woolley, J. P. Morton, O. J. Sansom, C. Hogan
This study shows that KRASG12D mutant cells are outcompeted by wild-type cells in the adult pancreas, dependent on EphA2 signaling, leading to tissue clearance and reduced premalignant lesions.
bioRxiv · Aug 4, 2020Cell Biology