Self-Assembly of Tunable Intrinsically DisorderedPeptide Amphiphiles
T. Ehm, H. Shinar, G. Jacoby, S. Meir, G. Koren, M. Segal Asher, J. Korpanty, M. P. Thompson, N. C. Gianneschi, M. M. Kozlov, S. E. Azoulay-Ginsbur, R. Amir, J. O. Raedler, R. Beck
This study investigates how sequence variations in IDPAs affect their self-assembly structures and phase transitions, showing that single amino acid mutations can tune mesophase behavior and enable enzymatic activation.
bioRxiv · Oct 28, 2022Biophysics